Projects
Portfolio of Work
Development of Cardiovascular Temporary Pacing Wires
Developed a device for the attachment of temporary epicardial pacing wires to the heart with the goal of mitigating damage to the cardiac tissue in collaboration with the Geisinger Medical Center cardiology team. Supported device development and design processes focused on problem identification, device fabrication and prototyping, failure modes and effects analysis (FMEA), and feasibility and verification testing. Created and maintained project documentation, including design functions, specifications, verification and validation reports in a well-established and organized the design history file (DHF). Participated in the Bucknell Senior Engineering Design Expo to present device prototype.
Cell Culture and Biocompatibility Testing
CITI Biosafety Level 2 Certified
Applied sterile techniques to successfully culture a line of Madin-Darby Canine Kidney (MDCK) cells and performed an in-vitro cytotoxicity assay to investigate the biocompatibility of different materials used in medical devices following ISO 10993, ASTM F748/F813 and AAMI 1999 standards. Utilized machine learning techniques for image recognition and compiled MATLAB algorithm and FIJI image processing code to automate biological image analysis including cell counting and characterization. Authored a comprehensive project report in collaboration with project team members
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Alveolar Airflow COMSOL Model for Pulmonary Drug Delivery
Applied computational fluid dynamics techniques to develop a fluid flow COMSOL model for pulmonary airflow and drug aerosol delivery in the alveoli. Carried out finite element analysis to determine effective aerosol flow rate and particle size to optimize aerosol drug delivery for COPD treatment. Explored applications of the model in treatment of other chronic diseases. Delivered project poster presentation to the public at Bucknell Senior Design Poster Presentation Expo.
Optimizing Chemotherapy Treatment - Engineering Computing & Modeling
Applied engineering computing techniques to develop a pharmacokinetic model for single drug chemotherapy to optimize treatment for eradicating tumors and reducing drug exposure. Developed a MATLAB GUI to carry out a parametric study focused on analyzing how tumor growth rate and fractional tumor cell kill by chemotherapy affect the tumor cell population.
Medical Imaging, Processing and Segmentation
Utilized ITK-SNAP software to segment anatomical structures in 3D clinical images (CT scan) for fabrication through 3D printing. Studied machine learning for use in image recognition and compiled MATLAB algorithm and ImageJ processing code to automate image analysis. Additionally explored applications of AI in healthcare.
Surface Functionalization - Techniques and Applications of Modifying Compression Garments for Lymphedema Treatment
Proposed new techniques for modifying compression garments to improve treatment for stage 3 lymphedema. Developed processes of functionalizing lymphedema compression garments with hydrogel-controlled drug delivery to treat skin infection and irritation.
Biomechanical Analysis of the effect of Body Posture and Load on the Back Angle and Moment
Performed Biomechanical analysis of the effect of body posture and load on the back angle and moment during the squat and stoop weightlifting technique. Captured full body motion data during weightlifting using VICON Motion Capture system and carried out data analysis using Excel.
Interactive Brain Interface
Designed an interactive “brain interface” exhibit for students to explore the relationship between muscle movement and brain stimulation. Recorded EMG signals during muscle movement to determine the intensity and location of brain stimulation and complied MATLAB algorithm to carry out EMG signal processing functions.
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Electrical Gizmo
Designed and fabricated a “snap circuit” exhibit to help students apply knowledge of the basic electrical circuits in designing and constructing simple direct current circuits according to Pennsylvania Educational Standards.
Medical Device Assessment & Development
Completed an examination of medical device design processes concentrated on problem identification, intellectual property, FDA regulatory pathways, and industry standards. Completed mechanical dissection and failure modes and effects analysis for mesh nebulizer and oxygen monitor. Proposed methods of improving continuous monitoring for sleep apnea and nebulization for COPD treatment.
Device Fabrication & Experimental Design
Produced various products for fabrication through laser cutting, 3D printing, and machining. Optimized designs following DFMA guidelines and created engineering drawings for device manufacturing in the product development laboratory.
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